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Charcot-Marie-Tooth Disease

Charcot-Marie-Tooth disease (CMT), is one of the most common inherited disorders of nerves that is characterized by loss of muscle and sensibility, predominantly in feet and legs but also in hands and arms in the advanced stages.

Schwann cells are the special kind of cells which create a sheath called myelin around the neurons so nerve signals are conducted faster, so together with the neurons they create a working nerve. The problem is that with CMT, some mutations cause a defect called demyelination in these cells so nerve signals are disrupted because of abnormal structure, malfunction or degeneration resulting in a reduced compound muscle action potential causing all muscle weakness, walking and balance problems among others.

World Stem Cells Clinic’s Advanced Stem Cell Therapy (ASCT) for Charcot-Marie-Tooth

A growing body of evidence suggests strongly that the use of stem cells to address the primary components of both inflammation and demyelination has a direct effect on this disease.

With the patient’s own adult stem cells, previously stimulated and then enhanced and expanded at our laboratory we address some of the underlying causes of the disease. Stem cells induce physical changes in the body to help it effectively regulate its immune response to heal and gain a better quality of life. Our studies have proven our stem cell protocol to be safe, and does not require complete suppression of the immune system.

A study designed and conducted at World Stem Cells Clinic for CMT successfully delivered:

  • Improvement in ability to walk.
  • Maintaining balance.
  • More consistent and higher levels of energy.
  • Strength and muscle control improvement.
  • Foot drop improvement.
  • Better reflexes.
  • Overall improvement in quality of life.

Our results indicate that circulating myeloid cells, in response to inflammatory cues, migrate to regenerating skeletal muscle and stochastically incorporate into mature myofibers inducing to muscle regeneration.

If you or a person you care about suffers from one of these or have any other related symptoms please do not hesitate to contact us to find out if we are conducting further studies.

News and references supporting our studies

Calandro. (2012). Stem Cell Line with Charcot-Marie-Tooth Available for Research. March, 2014, By National CMT Resource Center Web Site

MStem cells Laboratories. (2013). Stem Cell Research. March, 2014, By University of Michigan Web Site:http://www.stemcellresearch.umich.edu/overview/index.html

Hibaoui, Feki. (2012). Human Pluripotent Stem Cells: Applications and Challenges in Neurological Diseases. February, 2014, From NCBI Web Site: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429043/

Lindvall, Kokaia. (2006). Stem cells for the treatment of neurological disorders. INSIGHT PROGRESS, 441, 1094-1096.